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Dual Targeting of the Chemokine Receptors CXCR4 and ACKR3 with Novel Engineered Chemokines
The chemokine CXCL12 and its G protein-coupled receptors CXCR4 and ACKR3 are implicated in cancer and inflammatory and autoimmune disorders and are targets of numerous antagonist discovery efforts. Here, we describe a series of novel, high affinity CXCL12-based modulators of CXCR4 and ACKR3 generate...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4566214/ https://ncbi.nlm.nih.gov/pubmed/26216880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675108 |
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