The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, β-Arrestin-mediated Internalization

Activation of G protein-coupled receptors by their associated ligands has been extensively studied, and increasing structural information about the molecular mechanisms underlying ligand-dependent receptor activation is beginning to emerge with the recent expansion in GPCR crystal structures. Howeve...

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Autors principals: Gilliland, C. Taylor, Salanga, Catherina L., Kawamura, Tetsuya, Trejo, JoAnn, Handel, Tracy M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820859/
https://ncbi.nlm.nih.gov/pubmed/24056371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503797
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