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Structural Analysis of a Novel Small Molecule Ligand Bound to the CXCL12 Chemokine
[Image: see text] CXCL12 binds to CXCR4, promoting both chemotaxis of lymphocytes and metastasis of cancer cells. We previously identified small molecule ligands that bind CXCL12 and block CXCR4-mediated chemotaxis. We now report a 1.9 Å resolution X-ray structure of CXCL12 bound by such a molecule...
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| Publicado no: | J Med Chem |
|---|---|
| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255719/ https://ncbi.nlm.nih.gov/pubmed/25356720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501194p |
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