Structure-based identification of novel ligands targeting multiple sites within a chemokine-G protein–coupled receptor interface

CXCL12 is a human chemokine that recognizes the CXCR4 receptor and is involved in immune responses and metastatic cancer. Interactions between CXCL12 and CXCR4 are an important drug target but, like other elongated protein-protein interfaces, present challenges for small molecule ligand discovery du...

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Udgivet i:J Med Chem
Main Authors: Smith, Emmanuel W, Nevins, Amanda M, Qiao, Zhen, Liu, Yan, Getschman, Anthony E, Vankayala, Sai L, Kemp, M Trent, Peterson, Francis C, Li, Rongshi, Volkman, Brian F, Chen, Yu
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600900/
https://ncbi.nlm.nih.gov/pubmed/27058821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b02042
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