Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus

The ability to interact with cell surface glycosaminoglycans (GAGs) is essential to the cell migration properties of chemokines, but association with soluble GAGs induces the oligomerization of most chemokines including CXCL12. Monomeric CXCL12, but not dimeric CXCL12, is cardioprotective in a numbe...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ziarek, Joshua J., Veldkamp, Christopher T., Zhang, Fuming, Murray, Nathan J., Kartz, Gabriella A., Liang, Xinle, Su, Jidong, Baker, John E., Linhardt, Robert J., Volkman, Brian F.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2013
Θέματα:
Molecular Biophysics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537072/
https://ncbi.nlm.nih.gov/pubmed/23148226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394064
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια