Inhibition of Chemokine (CXC Motif) Ligand 12/Chemokine (CXC Motif) Receptor 4 Axis (CXCL12/CXCR4)-mediated Cell Migration by Targeting Mammalian Target of Rapamycin (mTOR) Pathway in Human Gastric Carcinoma Cells

CXCL12/CXCR4 plays an important role in metastasis of gastric carcinoma. Rapamycin has been reported to inhibit migration of gastric cancer cells. However, the role of mTOR pathway in CXCL12/CXCR4-mediated cell migration and the potential of drugs targeting PI3K/mTOR pathway remains unelucidated. We...

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Detalhes bibliográficos
Main Authors: Chen, Guang, Chen, Si-Meng, Wang, Xiang, Ding, Xiao-Fei, Ding, Jian, Meng, Ling-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320958/
https://ncbi.nlm.nih.gov/pubmed/22337890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.302299
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