Discovery and Characterization of a Disulfide-Locked C(2)-Symmetric Defensin Peptide

[Image: see text] We report the discovery of HD5-CD, an unprecedented C(2)-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys(II)–Cys(IV) (Cys(5)–Cys(2...

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Main Authors: Wommack, Andrew J., Ziarek, Joshua J., Tomaras, Jill, Chileveru, Haritha R., Zhang, Yunfei, Wagner, Gerhard, Nolan, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183617/
https://ncbi.nlm.nih.gov/pubmed/25181039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja505957w
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