Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

von van der Linden, Wouter A., Schulze, Christopher J., Herbert, Andrew S., Krause, Tyler B., Wirchnianski, Ariel A., Dye, John M., Chandran, Kartik, Bogyo, Matthew
Veröffentlicht in ACS Infect Dis (2016)

Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Responses in Mice

von Frei, Julia C., Wirchnianski, Ariel S., Govero, Jennifer, Vergnolle, Olivia, Dowd, Kimberly A., Pierson, Theodore C., Kielian, Margaret, Girvin, Mark E., Diamond, Michael S., Lai, Jonathan R.
Veröffentlicht in J Virol (2018)

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion

von Kleinfelter, Lara M., Jangra, Rohit K., Jae, Lucas T., Herbert, Andrew S., Mittler, Eva, Stiles, Katie M., Wirchnianski, Ariel S., Kielian, Margaret, Brummelkamp, Thijn R., Dye, John M., Chandran, Kartik
Veröffentlicht in mBio (2015)

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

von Ndungo, Esther, Herbert, Andrew S., Raaben, Matthijs, Obernosterer, Gregor, Biswas, Rohan, Miller, Emily Happy, Wirchnianski, Ariel S., Carette, Jan E., Brummelkamp, Thijn R., Whelan, Sean P., Dye, John M., Chandran, Kartik
Veröffentlicht in mSphere (2016)

Exploiting pre-existing CD4(+) T cell help from BCG vaccination to improve anti-viral antibody responses

von Ng, Tony W., Wirchnianski, Ariel S., Wec, Anna Z., Fels, J. Maximilian, Johndrow, Christopher T., Saunders, Kevin O., Liao, Hua-Xin, Chan, John, Jacobs, William R., Chandran, Kartik, Porcelli, Steven A.
Veröffentlicht in J Immunol (2020)

Lassa virus entry requires a trigger-induced receptor switch

von Jae, Lucas T., Raaben, Matthijs, Herbert, Andrew S., Kuehne, Ana I., Wirchnianski, Ariel S., Soh, Timothy, Stubbs, Sarah H., Janssen, Hans, Damme, Markus, Saftig, Paul, Whelan, Sean P., Dye, John M., Brummelkamp, Thijn R.
Veröffentlicht in Science (2014)

Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization

von Wang, Yimeng, Howell, Katie A., Brannan, Jennifer, Agans, Krystle N., Turner, Hannah L., Wirchnianski, Ariel S., Kailasan, Shweta, Fusco, Marnie, Galkin, Andrey, Chiang, Chi-I, Zhao, Xuelian, Saphire, Erica Ollmann, Chandran, Kartik, Ward, Andrew B., Dye, John M., Aman, M. Javad, Geisbert, Thomas W., Li, Yuxing
Veröffentlicht in J Virol (2021)

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody

von West, Brandyn R., Wec, Anna Z., Moyer, Crystal L., Fusco, Marnie L., Ilinykh, Philipp A., Huang, Kai, Wirchnianski, Ariel S., James, Rebekah M., Herbert, Andrew S., Hui, Sean, Goodwin, Eileen, Howell, Katie A., Kailasan, Shweta, Aman, M. Javad, Walker, Laura M., Dye, John M., Bukreyev, Alexander, Chandran, Kartik, Saphire, Erica Ollmann
Veröffentlicht in Nat Struct Mol Biol (2019)

Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein

von Keck, Zhen-Yong, Enterlein, Sven G., Howell, Katie A., Vu, Hong, Shulenin, Sergey, Warfield, Kelly L., Froude, Jeffrey W., Araghi, Nazli, Douglas, Robin, Biggins, Julia, Lear-Rooney, Calli M., Wirchnianski, Ariel S., Lau, Patrick, Wang, Yong, Herbert, Andrew S., Dye, John M., Glass, Pamela J., Holtsberg, Frederick W., Foung, Steven K. H., Aman, M. Javad
Veröffentlicht in J Virol (2015)

A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

von Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.
Veröffentlicht in bioRxiv (2020)

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

von Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.
Veröffentlicht in Cell Host Microbe (2020)

Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference

von Fels, J. Maximilian, Khan, Saad, Forster, Ryan, Skalina, Karin A., Sirichand, Surksha, Fox, Amy S., Bergman, Aviv, Mitchell, William B., Wolgast, Lucia R., Szymczak, Wendy, Bortz, Robert H., Dieterle, M. Eugenia, Florez, Catalina, Haslwanter, Denise, Jangra, Rohit K., Laudermilch, Ethan, Wirchnianski, Ariel S., Barnhill, Jason, Goldman, David L., Khine, Hnin, Goldstein, D. Yitzchak, Daily, Johanna P., Chandran, Kartik, Kelly, Libusha
Veröffentlicht in medRxiv (2022)

Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses

von Holtsberg, Frederick W., Shulenin, Sergey, Vu, Hong, Howell, Katie A., Patel, Sonal J., Gunn, Bronwyn, Karim, Marcus, Lai, Jonathan R., Frei, Julia C., Nyakatura, Elisabeth K., Zeitlin, Larry, Douglas, Robin, Fusco, Marnie L., Froude, Jeffrey W., Saphire, Erica Ollmann, Herbert, Andrew S., Wirchnianski, Ariel S., Lear-Rooney, Calli M., Alter, Galit, Dye, John M., Glass, Pamela J., Warfield, Kelly L., Aman, M. Javad
Veröffentlicht in J Virol (2015)

Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection

von Wec, Anna Z., Bornholdt, Zachary A., He, Shihua, Herbert, Andrew S., Goodwin, Eileen, Wirchnianski, Ariel S., Gunn, Bronwyn M., Zhang, Zirui, Zhu, Wenjun, Liu, Guodong, Abelson, Dafna M., Moyer, Crystal L., Jangra, Rohit K., James, Rebekah M., Bakken, Russell R., Bohorova, Natasha, Bohorov, Ognian, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Bortz, Robert H., Whaley, Kevin J., Goldstein, Tracey, Anthony, Simon J., Alter, Galit, Walker, Laura M., Dye, John M., Zeitlin, Larry, Qiu, Xiangguo, Chandran, Kartik
Veröffentlicht in Cell Host Microbe (2019)

Protocadherin-1 is essential for cell entry by New World hantaviruses

von Jangra, Rohit K., Herbert, Andrew S., Li, Rong, Jae, Lucas T., Kleinfelter, Lara M., Slough, Megan M., Barker, Sarah L., Guardado-Calvo, Pablo, Román-Sosa, Gleyder, Dieterle, M. Eugenia, Kuehne, Ana I., Muena, Nicolás A., Wirchnianski, Ariel S., Nyakatura, Elisabeth K., Fels, J. Maximilian, Ng, Melinda, Mittler, Eva, Pan, James, Bharrhan, Sushma, Wec, Anna Z., Lai, Jonathan r., Sidhu, Sachdev S., Tischler, Nicole D., rey, Félix A., Moffat, Jason, Brummelkamp, Thijn R., Wang, Zhongde, Dye, John M., Chandran, Kartik
Veröffentlicht in Nature (2018)

A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates

von Bornholdt, Zachary A., Herbert, Andrew S., Mire, Chad E., He, Shihua, Cross, Robert W., Wec, Anna Z., Abelson, Dafna M., Geisbert, Joan B., James, Rebekah M., Rahim, Md Niaz, Zhu, Wenjun, Borisevich, Viktoriya, Banadyga, Logan, Gunn, Bronwyn M., Agans, Krystle N., Wirchnianski, Ariel S., Goodwin, Eileen, Tierney, Kevin, Shestowsky, William S., Bohorov, Ognian, Bohorova, Natasha, Velasco, Jesus, Ailor, Eric, Kim, Do, Pauly, Michael H., Whaley, Kevin J., Alter, Galit, Walker, Laura M., Chandran, Kartik, Zeitlin, Larry, Qiu, Xiangguo, Geisbert, Thomas W., Dye, John M.
Veröffentlicht in Cell Host Microbe (2019)

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

von Wec, Anna Z., Wrapp, Daniel, Herbert, Andrew S., Maurer, Daniel, Haslwanter, Denise, Sakharkar, Mrunal, Jangra, Rohit K., Dieterle, M. Eugenia, Lilov, Asparouh, Huang, Deli, Tse, Longping V., Johnson, Nicole V., Hsieh, Ching-Lin, Wang, Nianshuang, Nett, Juergen H., Champney, Elizabeth, Burnina, Irina, Brown, Michael, Lin, Shu, Sinclair, Melanie, Johnson, Carl, Pudi, Sarat, Bortz, Robert, Wirchnianski, Ariel S., Laudermilch, Ethan, Florez, Catalina, Fels, J. Maximilian, O’Brien, Cecilia M., Graham, Barney S., Nemazee, David, Burton, Dennis R., Baric, Ralph S., Voss, James E., Chandran, Kartik, Dye, John M., McLellan, Jason S., Walker, Laura M.
Veröffentlicht in bioRxiv (2020)

Broad neutralization of SARS-related viruses by human monoclonal antibodies

von Wec, Anna Z., Wrapp, Daniel, Herbert, Andrew S., Maurer, Daniel P., Haslwanter, Denise, Sakharkar, Mrunal, Jangra, Rohit K., Dieterle, M. Eugenia, Lilov, Asparouh, Huang, Deli, Tse, Longping V., Johnson, Nicole V., Hsieh, Ching-Lin, Wang, Nianshuang, Nett, Juergen H., Champney, Elizabeth, Burnina, Irina, Brown, Michael, Lin, Shu, Sinclair, Melanie, Johnson, Carl, Pudi, Sarat, Bortz, Robert, Wirchnianski, Ariel S., Laudermilch, Ethan, Florez, Catalina, Fels, J. Maximilian, O’Brien, Cecilia M., Graham, Barney S., Nemazee, David, Burton, Dennis R., Baric, Ralph S., Voss, James E., Chandran, Kartik, Dye, John M., McLellan, Jason S., Walker, Laura M.
Veröffentlicht in Science (2020)

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

von Herrera, Natalia G., Morano, Nicholas C., Celikgil, Alev, Georgiev, George I., Malonis, Ryan J., Lee, James H., Tong, Karen, Vergnolle, Olivia, Massimi, Aldo B., Yen, Laura Y., Noble, Alex J., Kopylov, Mykhailo, Bonanno, Jeffrey B., Garrett-Thomson, Sarah C., Hayes, David B., Bortz, Robert H., Wirchnianski, Ariel S., Florez, Catalina, Laudermilch, Ethan, Haslwanter, Denise, Fels, J. Maximilian, Dieterle, M. Eugenia, Jangra, Rohit K., Barnhill, Jason, Mengotto, Amanda, Kimmel, Duncan, Daily, Johanna P., Pirofski, Liise-anne, Chandran, Kartik, Brenowitz, Michael, Garforth, Scott J., Eng, Edward T., Lai, Jonathan R., Almo, Steven C.
Veröffentlicht in bioRxiv (2020)

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

von Herrera, Natalia G., Morano, Nicholas C., Celikgil, Alev, Georgiev, George I., Malonis, Ryan J., Lee, James H., Tong, Karen, Vergnolle, Olivia, Massimi, Aldo B., Yen, Laura Y., Noble, Alex J., Kopylov, Mykhailo, Bonanno, Jeffrey B., Garrett-Thomson, Sarah C., Hayes, David B., Bortz, Robert H., Wirchnianski, Ariel S., Florez, Catalina, Laudermilch, Ethan, Haslwanter, Denise, Fels, J. Maximilian, Dieterle, M. Eugenia, Jangra, Rohit K., Barnhill, Jason, Mengotto, Amanda, Kimmel, Duncan, Daily, Johanna P., Pirofski, Liise-anne, Chandran, Kartik, Brenowitz, Michael, Garforth, Scott J., Eng, Edward T., Lai, Jonathan R., Almo, Steven C.
Veröffentlicht in ACS Omega (2020)