Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection

Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have entered clinical development are specific for a single member of the Ebolavirus genus, Ebola virus (EBOV), and ineffective against o...

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Publicado no:Cell Host Microbe
Main Authors: Wec, Anna Z., Bornholdt, Zachary A., He, Shihua, Herbert, Andrew S., Goodwin, Eileen, Wirchnianski, Ariel S., Gunn, Bronwyn M., Zhang, Zirui, Zhu, Wenjun, Liu, Guodong, Abelson, Dafna M., Moyer, Crystal L., Jangra, Rohit K., James, Rebekah M., Bakken, Russell R., Bohorova, Natasha, Bohorov, Ognian, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Bortz, Robert H., Whaley, Kevin J., Goldstein, Tracey, Anthony, Simon J., Alter, Galit, Walker, Laura M., Dye, John M., Zeitlin, Larry, Qiu, Xiangguo, Chandran, Kartik
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396299/
https://ncbi.nlm.nih.gov/pubmed/30629917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.12.004
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