Rapid High Yield Production of Different Glycoforms of Ebola Virus Monoclonal Antibody

BACKGROUND: Fc-glycosylation of monoclonal antibodies (mAbs) has profound implications on the Fc-mediated effector functions. Alteration of this glycosylation may affect the efficiency of an antibody. However, difficulties in the production of mAbs with homogeneous N-glycosylation profiles in suffic...

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Hlavní autoři: Castilho, Alexandra, Bohorova, Natasha, Grass, Josephine, Bohorov, Ognian, Zeitlin, Larry, Whaley, Kevin, Altmann, Friedrich, Steinkellner, Herta
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3200319/
https://ncbi.nlm.nih.gov/pubmed/22039433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026040
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