Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection

Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have entered clinical development are specific for a single member of the Ebolavirus genus, Ebola virus (EBOV), and ineffective against o...

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Publicat a:Cell Host Microbe
Autors principals: Wec, Anna Z., Bornholdt, Zachary A., He, Shihua, Herbert, Andrew S., Goodwin, Eileen, Wirchnianski, Ariel S., Gunn, Bronwyn M., Zhang, Zirui, Zhu, Wenjun, Liu, Guodong, Abelson, Dafna M., Moyer, Crystal L., Jangra, Rohit K., James, Rebekah M., Bakken, Russell R., Bohorova, Natasha, Bohorov, Ognian, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Bortz, Robert H., Whaley, Kevin J., Goldstein, Tracey, Anthony, Simon J., Alter, Galit, Walker, Laura M., Dye, John M., Zeitlin, Larry, Qiu, Xiangguo, Chandran, Kartik
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396299/
https://ncbi.nlm.nih.gov/pubmed/30629917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.12.004
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