Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody

The structural features that govern broad-spectrum activity of broadly neutralizing, anti-ebolavirus antibodies (Abs) outside of the internal fusion loop epitope are currently unknown. Here we describe the structure of a broadly neutralizing human monoclonal Ab (mAb), ADI-15946, which was identified...

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Publicado no:Nat Struct Mol Biol
Main Authors: West, Brandyn R., Wec, Anna Z., Moyer, Crystal L., Fusco, Marnie L., Ilinykh, Philipp A., Huang, Kai, Wirchnianski, Ariel S., James, Rebekah M., Herbert, Andrew S., Hui, Sean, Goodwin, Eileen, Howell, Katie A., Kailasan, Shweta, Aman, M. Javad, Walker, Laura M., Dye, John M., Bukreyev, Alexander, Chandran, Kartik, Saphire, Erica Ollmann
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402988/
https://ncbi.nlm.nih.gov/pubmed/30833785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0191-4
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