A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses

There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential interaction between the filovirus glycoprotein, GP, and its entry receptor Niemann-Pick C1 (NPC1) provides an attractive target for such mAbs but i...

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Publicado no:Science
Main Authors: Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Howell, Katie A., Holtsberg, Frederick W., Bakken, Russell R., Mittler, Eva, Christin, John R., Shulenin, Sergey, Jangra, Rohit K., Bharrhan, Sushma, Kuehne, Ana I., Bornholdt, Zachary A., Flyak, Andrew I., Saphire, Erica Ollmann, Crowe, James E, Aman, M. Javad, Dye, John M., Lai, Jonathan R., Chandran, Kartik
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647781/
https://ncbi.nlm.nih.gov/pubmed/27608667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag3267
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