A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses

There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential interaction between the filovirus glycoprotein, GP, and its entry receptor Niemann-Pick C1 (NPC1) provides an attractive target for such mAbs but i...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Howell, Katie A., Holtsberg, Frederick W., Bakken, Russell R., Mittler, Eva, Christin, John R., Shulenin, Sergey, Jangra, Rohit K., Bharrhan, Sushma, Kuehne, Ana I., Bornholdt, Zachary A., Flyak, Andrew I., Saphire, Erica Ollmann, Crowe, James E, Aman, M. Javad, Dye, John M., Lai, Jonathan R., Chandran, Kartik
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647781/
https://ncbi.nlm.nih.gov/pubmed/27608667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag3267
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