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Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism
Recognition of viral double-stranded RNA (dsRNA) activates interferon production and immune signaling in host cells. Crystal structures of ebolavirus VP35 show that it caps dsRNA ends to prevent sensing by pattern recognition receptors such as RIG-I. In contrast, structures of marburgvirus VP35 show...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753998/ https://ncbi.nlm.nih.gov/pubmed/23824825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01452-13 |
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