Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

Filoviruses, including Marburg virus (MARV) and Ebola virus (EBOV), cause fatal hemorrhagic fever in humans and non-human primates. All filoviruses encode a unique multi-functional protein termed VP35. The C-terminal double-stranded (ds)RNA-binding domain (RBD) of VP35 has been implicated in interfe...

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Détails bibliographiques
Auteurs principaux: Bale, Shridhar, Julien, Jean-Philippe, Bornholdt, Zachary A., Kimberlin, Christopher R., Halfmann, Peter, Zandonatti, Michelle A., Kunert, John, Kroon, Gerard J. A., Kawaoka, Yoshihiro, MacRae, Ian J., Wilson, Ian A., Saphire, Erica Ollmann
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441732/
https://ncbi.nlm.nih.gov/pubmed/23028316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002916
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