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Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope

Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in complex with Ebola virus and Bundibugyo virus glycoproteins (GPs)...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: West, Brandyn R., Moyer, Crystal L., King, Liam B., Fusco, Marnie L., Milligan, Jacob C., Hui, Sean, Saphire, Erica Ollmann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134094/
https://ncbi.nlm.nih.gov/pubmed/30206174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01674-18
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