Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope

Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in complex with Ebola virus and Bundibugyo virus glycoproteins (GPs)...

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Bibliographic Details
Published in:mBio
Main Authors: West, Brandyn R., Moyer, Crystal L., King, Liam B., Fusco, Marnie L., Milligan, Jacob C., Hui, Sean, Saphire, Erica Ollmann
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134094/
https://ncbi.nlm.nih.gov/pubmed/30206174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01674-18
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