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Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope

Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in complex with Ebola virus and Bundibugyo virus glycoproteins (GPs)...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:mBio
Prif Awduron: West, Brandyn R., Moyer, Crystal L., King, Liam B., Fusco, Marnie L., Milligan, Jacob C., Hui, Sean, Saphire, Erica Ollmann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134094/
https://ncbi.nlm.nih.gov/pubmed/30206174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01674-18
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