Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections. Here, we mined the memory B cell repertoire of a conv...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Wec, Anna Z., Wrapp, Daniel, Herbert, Andrew S., Maurer, Daniel, Haslwanter, Denise, Sakharkar, Mrunal, Jangra, Rohit K., Dieterle, M. Eugenia, Lilov, Asparouh, Huang, Deli, Tse, Longping V., Johnson, Nicole V., Hsieh, Ching-Lin, Wang, Nianshuang, Nett, Juergen H., Champney, Elizabeth, Burnina, Irina, Brown, Michael, Lin, Shu, Sinclair, Melanie, Johnson, Carl, Pudi, Sarat, Bortz, Robert, Wirchnianski, Ariel S., Laudermilch, Ethan, Florez, Catalina, Fels, J. Maximilian, O’Brien, Cecilia M., Graham, Barney S., Nemazee, David, Burton, Dennis R., Baric, Ralph S., Voss, James E., Chandran, Kartik, Dye, John M., McLellan, Jason S., Walker, Laura M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241100/
https://ncbi.nlm.nih.gov/pubmed/32511337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.15.096511
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