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Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections. Here, we mined the memory B cell repertoire of a conv...

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Bibliografische gegevens
Gepubliceerd in:bioRxiv
Hoofdauteurs: Wec, Anna Z., Wrapp, Daniel, Herbert, Andrew S., Maurer, Daniel, Haslwanter, Denise, Sakharkar, Mrunal, Jangra, Rohit K., Dieterle, M. Eugenia, Lilov, Asparouh, Huang, Deli, Tse, Longping V., Johnson, Nicole V., Hsieh, Ching-Lin, Wang, Nianshuang, Nett, Juergen H., Champney, Elizabeth, Burnina, Irina, Brown, Michael, Lin, Shu, Sinclair, Melanie, Johnson, Carl, Pudi, Sarat, Bortz, Robert, Wirchnianski, Ariel S., Laudermilch, Ethan, Florez, Catalina, Fels, J. Maximilian, O’Brien, Cecilia M., Graham, Barney S., Nemazee, David, Burton, Dennis R., Baric, Ralph S., Voss, James E., Chandran, Kartik, Dye, John M., McLellan, Jason S., Walker, Laura M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241100/
https://ncbi.nlm.nih.gov/pubmed/32511337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.15.096511
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