P-glycoprotein is fully active after multiple tryptophan substitutions

Por Swartz, Douglas J., Weber, Joachim, Urbatsch, Ina L.
Publicado em 2012

Specific Lipids Modulate the Transporter Associated with Antigen Processing (TAP)

Por Schölz, Christian, Parcej, David, Ejsing, Christer S., Robenek, Horst, Urbatsch, Ina L., Tampé, Robert
Publicado em 2011

Design and Synthesis of Selenazole-Containing Peptides for Cocrystallization with P-Glycoprotein

Por Tao, Houchao, Weng, Yue, Zhuo, Rupeng, Chang, Geoffrey, Urbatsch, Ina L., Zhang, Qinghai
Publicado no Chembiochem (2011)

Specific Stabilization of CFTR by Phosphatidylserine

Por Hildebrandt, Ellen, Khazanov, Netaly, Kappes, John C., Dai, Qun, Senderowitz, Hanoch, Urbatsch, Ina L.
Publicado no Biochim Biophys Acta (2016)

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1

Por Gutmann, Daniel A. P., Ward, Andrew, Urbatsch, Ina L., Chang, Geoffrey, van Veen, Hendrik W.
Publicado no Trends Biochem Sci (2009)

Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance

Por Swartz, Douglas J., Mok, Leo, Botta, Sri K., Singh, Anukriti, Altenberg, Guillermo A., Urbatsch, Ina L.
Publicado em 2014

Asymmetry in inward- and outward-affinity constant of transport explain unidirectional lysine flux in Saccharomyces cerevisiae

Por Bianchi, Frans, Klooster, Joury S. van ‘t, Ruiz, Stephanie J., Luck, Katja, Pols, Tjeerd, Urbatsch, Ina L., Poolman, Bert
Publicado no Sci Rep (2016)

Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer–associated P-glycoprotein during ATP hydrolysis

Por Zoghbi, Maria E., Mok, Leo, Swartz, Douglas J., Singh, Anukriti, Fendley, Gregory A., Urbatsch, Ina L., Altenberg, Guillermo A.
Publicado no J Biol Chem (2017)

Distinct Conformational Spectrum of Homologous Multidrug ABC Transporters

Por Moeller, Arne, Lee, Sung Chang, Tao, Houchao, Speir, Jeffrey A., Chang, Geoffrey, Urbatsch, Ina L., Potter, Clinton S., Carragher, Bridget, Zhang, Qinghai
Publicado no Structure (2015)

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Por Aller, Stephen G., Yu, Jodie, Ward, Andrew, Weng, Yue, Chittaboina, Srinivas, Zhuo, Rupeng, Harrell, Patina M., Trinh, Yenphuong T., Zhang, Qinghai, Urbatsch, Ina L., Chang, Geoffrey
Publicado em 2009

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

Por Szewczyk, Paul, Tao, Houchao, McGrath, Aaron P., Villaluz, Mark, Rees, Steven D., Lee, Sung Chang, Doshi, Rupak, Urbatsch, Ina L., Zhang, Qinghai, Chang, Geoffrey
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

A Survey of Detergents for the Purification of Stable, Active Human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Por Hildebrandt, Ellen, Zhang, Qinghai, Cant, Natasha, Ding, Haitao, Dai, Qun, Peng, Lingling, Fu, Yu, DeLucas, Lawrence J., Ford, Robert, Kappes, John C., Urbatsch, Ina L.
Publicado em 2014

A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

Por Bai, Jiangping, Swartz, Douglas J., Protasevich, Irina I., Brouillette, Christie G., Harrell, Patina M., Hildebrandt, Ellen, Gasser, Brigitte, Mattanovich, Diethard, Ward, Andrew, Chang, Geoffrey, Urbatsch, Ina L.
Publicado em 2011

Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains

Por Yang, Zhengrong, Wang, Chi, Zhou, Qingxian, An, Jianli, Hildebrandt, Ellen, Aleksandrov, Luba A, Kappes, John C, DeLucas, Lawrence J, Riordan, John R, Urbatsch, Ina L, Hunt, John F, Brouillette, Christie G
Publicado em 2014

Crystal structure of the human sterol transporter ABCG5/ABCG8

Por Lee, Jyh-Yeuan, Kinch, Lisa N., Borek, Dominika M., Wang, Jin, Wang, Junmei, Urbatsch, Ina L., Xie, Xiao-Song, Grishin, Nikolai V., Cohen, Jonathan C., Otwinowski, Zbyszek, Hobbs, Helen H., Rosenbaum, Daniel M.
Publicado no Nature (2016)

Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1

Por Yang, Zhengrong, Hildebrandt, Ellen, Jiang, Fan, Aleksandrov, Andrei, Khazanov, Netaly, Zhou, Qingxian, An, Jianli, Mezzell, Andrew T., Xavier, Bala M., Ding, Haitao, Riordan, John R., Senderowitz, Hanoch, Kappes, John C., Brouillette, Christie G., Urbatsch, Ina L.
Publicado no Biochim Biophys Acta Biomembr (2018)

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Por Ward, Andrew B., Szewczyk, Paul, Grimard, Vinciane, Lee, Chang-Wook, Martinez, Lorena, Doshi, Rupak, Caya, Alexandra, Villaluz, Mark, Pardon, Els, Cregger, Cristina, Swartz, Douglas J., Falson, Pierre Guy, Urbatsch, Ina L., Govaerts, Cedric, Steyaert, Jan, Chang, Geoffrey
Publicado em 2013

A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface

Por Hildebrandt, Ellen, Mulky, Alok, Ding, Haitao, Dai, Qun, Aleksandrov, Andrei A., Bajrami, Bekim, Diego, Pamela Ann, Wu, Xing, Ray, Marjorie, Naren, Anjaparavanda P., Riordan, John R., Yao, Xudong, DeLucas, Lawrence J., Urbatsch, Ina L., Kappes, John C.
Publicado no Mol Biotechnol (2015)