Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

P-glycoprotein (P-gp) is one of the best-known mediators of drug efflux-based multidrug resistance in many cancers. This validated therapeutic target is a prototypic, plasma membrane resident ATP-Binding Cassette transporter that pumps xenobiotic compounds out of cells. The large, polyspecific drug-...

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Bibliographic Details
Main Authors: Ward, Andrew B., Szewczyk, Paul, Grimard, Vinciane, Lee, Chang-Wook, Martinez, Lorena, Doshi, Rupak, Caya, Alexandra, Villaluz, Mark, Pardon, Els, Cregger, Cristina, Swartz, Douglas J., Falson, Pierre Guy, Urbatsch, Ina L., Govaerts, Cedric, Steyaert, Jan, Chang, Geoffrey
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746859/
https://ncbi.nlm.nih.gov/pubmed/23901103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309275110
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