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Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein
P-glycoprotein (P-gp) is a transporter of great clinical and pharmacological significance. Several structural studies of P-gp and its homologs have provided insights into its transport cycle, but questions remain regarding how P-gp recognizes diverse substrates and how substrate binding is coupled t...
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| Publicado no: | Acta Crystallogr D Biol Crystallogr |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356375/ https://ncbi.nlm.nih.gov/pubmed/25760620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715000978 |
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