UNDERSTANDING POLYSPECIFICITY WITHIN THE SUBSTRATE-BINDING CAVITY OF THE HUMAN MULTIDRUG RESISTANCE P-GLYCOPROTEIN

Human P-glycoprotein (P-gp) controls drugs bioavailability by pumping out of the cells many structurally-unrelated drugs. The x-ray structure of the mouse P-gp ortholog was solved with two SSS- and one RRR-enantiomers of the selenohexapeptide inhibitor QZ59, found within the putative drug-binding po...

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發表在:FEBS J
Main Authors: Martinez, Lorena, Arnaud, Ophélie, Henin, Emilie, Tao, Houchao, Chaptal, Vincent, Doshi, Rupak, Andrieu, Thibaud, Dussurgey, Sébastien, Tod, Michel, Di Pietro, Attilio, Zhang, Qinghai, Chang, Geoffrey, Falson, Pierre
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663232/
https://ncbi.nlm.nih.gov/pubmed/24219411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12613
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