Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

P-glycoprotein (P-gp) is a polyspecific ATP-dependent transporter linked to multidrug resistance in cancer; it plays important roles in determining the pharmacokinetics of many drugs. Understanding the structural basis of P-gp, substrate polyspecificity has been hampered by its intrinsic flexibility...

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Udgivet i:J Biol Chem
Main Authors: Esser, Lothar, Zhou, Fei, Pluchino, Kristen M., Shiloach, Joseph, Ma, Jichun, Tang, Wai-kwan, Gutierrez, Camilo, Zhang, Alex, Shukla, Suneet, Madigan, James P., Zhou, Tongqing, Kwong, Peter D., Ambudkar, Suresh V., Gottesman, Michael M., Xia, Di
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241723/
https://ncbi.nlm.nih.gov/pubmed/27864369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.755884
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