Crystal structure of the human sterol transporter ABCG5/ABCG8

ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines(1–5). Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol a...

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Udgivet i:Nature
Main Authors: Lee, Jyh-Yeuan, Kinch, Lisa N., Borek, Dominika M., Wang, Jin, Wang, Junmei, Urbatsch, Ina L., Xie, Xiao-Song, Grishin, Nikolai V., Cohen, Jonathan C., Otwinowski, Zbyszek, Hobbs, Helen H., Rosenbaum, Daniel M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964963/
https://ncbi.nlm.nih.gov/pubmed/27144356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17666
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