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Crystal structure of the human sterol transporter ABCG5/ABCG8
ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines(1–5). Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol a...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4964963/ https://ncbi.nlm.nih.gov/pubmed/27144356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17666 |
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