Subsite specificity of anthrax lethal factor and its implications for inhibitor development

Por Li, Feng, Terzyan, Simon, Tang, Jordan
Publicado em 2011

Lethal Factor of Anthrax Toxin Binds Monomeric Form of Protective Antigen

Por Chvyrkova, Irina, Zhang, Xuejun C., Terzyan, Simon
Publicado em 2007

Structure of 6‐diazo‐5‐oxo‐norleucine‐bound human gamma‐glutamyl transpeptidase 1, a novel mechanism of inactivation

Por Terzyan, Simon S., Cook, Paul F., Heroux, Annie, Hanigan, Marie H.
Publicado no Protein Sci (2017)

The Major Neutralizing Antibody Responses to Recombinant Anthrax Lethal and Edema Factors Are Directed to Non-Cross-Reactive Epitopes

Por Nguyen, Melissa L., Terzyan, Simon, Ballard, Jimmy D., James, Judith A., Farris, A. Darise
Publicado em 2009

Accommodating a Non-Conservative Internal Mutation by Water-Mediated Hydrogen-Bonding Between β-Sheet Strands: A Comparison of Human and Rat Type B (Mitochondrial) Cytochrome b(5)

Por Parthasarathy, Sudharsan, Altuve, Adriana, Terzyan, Simon, Zhang, Xuejun, Kuczera, Krzysztof, Rivera, Mario, Benson, David R.
Publicado no Biochemistry (2011)

Using Substrate Specificity of Antiplasmin-Cleaving Enzyme for Fibroblast Activation Protein Inhibitor Design()

Por Lee, Kyung N., Jackson, Kenneth W., Terzyan, Simon, Christiansen, Victoria J., McKee, Patrick A.
Publicado no Biochemistry (2009)

Inhibition of anthrax lethal factor, lability of hydroxamate as a chelating group

Por Li, Feng, Chvyrkova, Irina, Terzyan, Simon, Wakeham, Nancy, Turner, Robert, Ghosh, Arun K., Zhang, Xuejun C., Tang, Jordan
Publicado em 2012

Human γ-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE...

Por Terzyan, Simon S., Burgett, Anthony W. G., Heroux, Annie, Smith, Clyde A., Mooers, Blaine H. M., Hanigan, Marie H.
Publicado no J Biol Chem (2015)

Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site

Por Terzyan, Simon S., Nguyen, Luong T., Burgett, Anthony W.G., Heroux, Annie, Smith, Clyde A., You, Youngjae, Hanigan, Marie H.
Publicado no J Biol Chem (2020)

Structure-Based Design of Highly Selective β-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure

Por Ghosh, Arun K., Rao, Kalapala Venkateswara, Yadav, Navnath D., Anderson, David D., Gavande, Navnath, Huang, Xiangping, Terzyan, Simon, Tang, Jordan
Publicado em 2012

Inhibition of human gamma-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors

Por Wickham, Stephanie, Regan, Nicholas, West, Matthew B., Thai, Justin, Cook, Paul F., Terzyan, Simon S., Li, Pui Kai, Hanigan, Marie H.
Publicado em 2013

Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib

Por Terzyan, Simon S., Shen, Tao, Liu, Xuan, Huang, Qingling, Teng, Peng, Zhou, Mi, Hilberg, Frank, Cai, Jianfeng, Mooers, Blaine H. M., Wu, Jie
Publicado no J Biol Chem (2019)

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

Por Zhu, Guangyu, Chen, Jia, Liu, Jay, Brunzelle, Joseph S, Huang, Bo, Wakeham, Nancy, Terzyan, Simon, Li, Xuemei, Rao, Zihe, Li, Guangpu, Zhang, Xuejun C
Publicado em 2007

Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases

Por Yarla, Nagendra Sastri, Pathuri, Gopal, Gali, Hariprasad, Terzyan, Simon, Panneerselvam, Janani, Chandrakesan, Parthasarathy, Scotti, Marcus Tullius, Houchen, Courtney, Madka, Venkateshwar, Rao, Chinthalapally V
Publicado no J Inflamm Res (2020)

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force

Por Mehta-D'souza, Padmaja, Klopocki, Arkadiusz G., Oganesyan, Vaheh, Terzyan, Simon, Mather, Timothy, Li, Zhenhai, Panicker, Sumith R., Zhu, Cheng, McEver, Rodger P.
Publicado no J Biol Chem (2017)

Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody

Por Ramsland, Paul A., Terzyan, Simon S., Cloud, Gwendolyn, Bourne, Christina R., Farrugia, William, Tribbick, Gordon, Geysen, H. Mario, Moomaw, Carolyn R., Slaughter, Clive A., Edmundson, Allen B.
Publicado em 2006