Inhibition of human gamma-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors

Gamma-glutamyl transpeptidase (GGT) is an essential enzyme for maintaining cysteine homeostasis, leukotriene synthesis, metabolism of glutathione-conjugates and catabolism of extracellular glutathione. Overexpression of GGT has been implicated in many pathologies, and clinical inhibitors of GGT are...

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Bibliografiske detaljer
Main Authors: Wickham, Stephanie, Regan, Nicholas, West, Matthew B., Thai, Justin, Cook, Paul F., Terzyan, Simon S., Li, Pui Kai, Hanigan, Marie H.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836663/
https://ncbi.nlm.nih.gov/pubmed/23301618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121435
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