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A Novel, Species-specific Class of Uncompetitive Inhibitors of γ-Glutamyl Transpeptidase
Expression of γ-glutamyl transpeptidase (GGT) in tumors contributes to resistance to radiation and chemotherapy. GGT is inhibited by glutamine analogues that compete with the substrate for the γ-glutamyl binding site. However, the glutamine analogues that have been evaluated in clinical trials are t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666554/ https://ncbi.nlm.nih.gov/pubmed/19203993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809608200 |
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