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Structure-Based Design of Highly Selective β-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure
Structure-based design, synthesis and X-ray structure of protein-ligand complexes of exceptionally potent and selective β-secretase inhibitors are described. The inhibitors are designed specifically to interact with S(1)′ active site residues to provide selectivity over memapsin 1 and cathepsin D. I...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3493683/ https://ncbi.nlm.nih.gov/pubmed/22954357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008823 |
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