Llwytho...

Structure-Based Design of Highly Selective β-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure

Structure-based design, synthesis and X-ray structure of protein-ligand complexes of exceptionally potent and selective β-secretase inhibitors are described. The inhibitors are designed specifically to interact with S(1)′ active site residues to provide selectivity over memapsin 1 and cathepsin D. I...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ghosh, Arun K., Rao, Kalapala Venkateswara, Yadav, Navnath D., Anderson, David D., Gavande, Navnath, Huang, Xiangping, Terzyan, Simon, Tang, Jordan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493683/
https://ncbi.nlm.nih.gov/pubmed/22954357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008823
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