Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies

We herein present the design, synthesis, and biological evaluation of potent and highly selective β-secretase 2 (memapsin 1, beta-site amyloid precursor protein cleaving enzyme 2 or BACE 2) inhibitors. BACE2 has been recognized as an exciting new target for type 2 diabetes. The X-ray structure of BA...

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Published in:ChemMedChem
Main Authors: Ghosh, Arun K., Brindisi, Margherita, Yen, Yu-Chen, Lendy, Emma K., Kovela, Satish, Cárdenas, Emilio Leal, Reddy, Bhavanam Sekhara, Rao, Kalapala Venketeswara, Downs, Deborah, Huang, Xiangping, Tang, Jordan, Mesecar, Andrew D.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637425/
https://ncbi.nlm.nih.gov/pubmed/30637955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800725
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