Structure-Based Design, Synthesis, and Biological Evaluation of Dihydroquinazoline-Derived Potent β-Secretase Inhibitors

Structure-based design, synthesis, and biological evaluation of a series of dihydroquinazoline-derived β-secretase inhibitors incorporating thiazole and pyrazole-derived P2-ligands are described. We have identified inhibitor 4f which has shown potent enzyme inhibitory (K(i) = 13 nM) and cellular (IC...

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Detalhes bibliográficos
Main Authors: Ghosh, Arun K., Pandey, Satyendra, Gangarajula, Sudhakar, Kulkarni, Sarang, Xu, Xiaoming, Rao, Kalapala Venkateswara, Huang, Xiangping, Tang, Jordan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423587/
https://ncbi.nlm.nih.gov/pubmed/22863204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.07.043
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