تحميل...
Structure-Based Design, Synthesis, and Biological Evaluation of Dihydroquinazoline-Derived Potent β-Secretase Inhibitors
Structure-based design, synthesis, and biological evaluation of a series of dihydroquinazoline-derived β-secretase inhibitors incorporating thiazole and pyrazole-derived P2-ligands are described. We have identified inhibitor 4f which has shown potent enzyme inhibitory (K(i) = 13 nM) and cellular (IC...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
2012
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423587/ https://ncbi.nlm.nih.gov/pubmed/22863204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.07.043 |
| الوسوم: |
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