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Enantioselective Total Synthesis of (+)-Largazole, a Potent Inhibitor of Histone Deacetylase
[Image: see text] An enantioselective total synthesis of cytotoxic natural product, (+)-largazole (1) is described. It is a potent histone deacetylase inhibitor. Our synthesis is convergent and involves the assembly of thiazole 3-derived carboxylic acid with amino ester 4 followed by cycloamidation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945909/ https://ncbi.nlm.nih.gov/pubmed/18662003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol8014623 |
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