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Modular Synthesis and Biological Activity of Pyridyl-based Analogs of the Potent Class I Histone Deacetylase Inhibitor Largazole
The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished. The synthetic strategy was designed modularly to access multiple inhibitors with different aryl fun...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4626217/ https://ncbi.nlm.nih.gov/pubmed/26054247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.03.063 |
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