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Synthesis and Biochemical Evaluation of Biotinylated Conjugates of Largazole Analogues: Selective Class I Histone Deacetylase Inhibitors
The synthesis of biotinylated conjugates of synthetic analogues of the potent and selective histone deacetylase (HDAC) inhibitor largazole is reported. The thiazole moiety of the parent compound’s cap group was derivatized to allow the chemical conjugation to biotin. The derivatized largazole analog...
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| Publicado no: | Isr J Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370329/ https://ncbi.nlm.nih.gov/pubmed/30760938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijch.201600130 |
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