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Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties
We describe here the enantioselective synthesis of (+)-monocerin and its acetate derivative. The present synthesis features an efficient optically active synthesis of the β-hydroxy-γ-lactone derivative with high enantiomeric purity using a Sharpless dihydroxylation as the key step. The synthesis als...
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| Izdano u: | J Org Chem |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6637414/ https://ncbi.nlm.nih.gov/pubmed/31033292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b00414 |
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