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Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties

We describe here the enantioselective synthesis of (+)-monocerin and its acetate derivative. The present synthesis features an efficient optically active synthesis of the β-hydroxy-γ-lactone derivative with high enantiomeric purity using a Sharpless dihydroxylation as the key step. The synthesis als...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Org Chem
Päätekijät: Ghosh, Arun K., Lee, Daniel S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637414/
https://ncbi.nlm.nih.gov/pubmed/31033292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b00414
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