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Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor

[Image: see text] An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a...

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Detalhes bibliográficos
Main Authors: Ghosh, Arun K., Anderson, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482479/
https://ncbi.nlm.nih.gov/pubmed/22954141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol301886g
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