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Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor
[Image: see text] An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482479/ https://ncbi.nlm.nih.gov/pubmed/22954141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol301886g |
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