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Enantioselective Syntheses of FR901464 and Spliceostatin A: Potent Inhibitors of Spliceosome

[Image: see text] Enantioselective syntheses of FR901464 and Spliceostatin A, potent spliceosome inhibitors are described. The synthesis of FR901464 has been accomplished in a convergent manner in 10 linear steps (20 total steps). The synthesis of the A-tetrahydropyran ring was constructed from (R)-...

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Autori principali: Ghosh, Arun K., Chen, Zhi-Hua
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827971/
https://ncbi.nlm.nih.gov/pubmed/24050251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol4024634
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