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Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives
[Image: see text] FR901464 (1) and spliceostatin A (2) are potent inhibitors of spliceosomes. These compounds have shown remarkable anticancer activity against multiple human cancer cell lines. Herein, we describe efficient, enantioselective syntheses of FR901464, spliceostatin A, six corresponding...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical
Society
2014
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066912/ https://ncbi.nlm.nih.gov/pubmed/24873648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo500800k |
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