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Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives

[Image: see text] FR901464 (1) and spliceostatin A (2) are potent inhibitors of spliceosomes. These compounds have shown remarkable anticancer activity against multiple human cancer cell lines. Herein, we describe efficient, enantioselective syntheses of FR901464, spliceostatin A, six corresponding...

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Detalhes bibliográficos
Main Authors: Ghosh, Arun K., Chen, Zhi-Hua, Effenberger, Kerstin A., Jurica, Melissa S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066912/
https://ncbi.nlm.nih.gov/pubmed/24873648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo500800k
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