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Enantioselective Total Synthesis of (+)-Largazole, a Potent Inhibitor of Histone Deacetylase

[Image: see text] An enantioselective total synthesis of cytotoxic natural product, (+)-largazole (1) is described. It is a potent histone deacetylase inhibitor. Our synthesis is convergent and involves the assembly of thiazole 3-derived carboxylic acid with amino ester 4 followed by cycloamidation...

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Bibliografiske detaljer
Main Authors: Ghosh, Arun K., Kulkarni, Sarang
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945909/
https://ncbi.nlm.nih.gov/pubmed/18662003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol8014623
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