Design, synthesis, and X-ray structural studies of BACE-1 Inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

We report the design and synthesis of a series of BACE1 inhibitors incorporating mono-and bicyclic 6-substituted 2-oxopiperazines as novel P1′ and P2′ ligands and isophthalamide derivative as P2-P3 ligands. Among mono-substituted 2-oxopiperazinones, inhibitor 5a with N-benzyl-2-oxopiperazinone and i...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Ghosh, Arun K., Brindisi, Margherita, Yen, Yu-Chen, Cárdenas, Emilio L., Ella-Menye, Jean-Rene, Kumaragurubaran, Nagaswamy, Huang, Xiangping, Tang, Jordan, Mesecar, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479133/
https://ncbi.nlm.nih.gov/pubmed/28427814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.04.011
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