Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors

BACE1 (Beta-site Amyloid Precursor Protein (APP) Cleaving Enzyme 1) is a promising therapeutic target for Alzheimer’s Disease (AD). However, efficient expression, purification, and crystallization systems are not well described or detailed in the literature nor are approaches for treatment of enzyme...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Yen, Yu-Chen, Kammeyer, Annalissa M., Jensen, Katherine C., Tirlangi, Jagannadharao, Ghosh, Arun K., Mesecar, Andrew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7284891/
https://ncbi.nlm.nih.gov/pubmed/31549827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00714
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