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Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors
BACE1 (Beta-site Amyloid Precursor Protein (APP) Cleaving Enzyme 1) is a promising therapeutic target for Alzheimer’s Disease (AD). However, efficient expression, purification, and crystallization systems are not well described or detailed in the literature nor are approaches for treatment of enzyme...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7284891/ https://ncbi.nlm.nih.gov/pubmed/31549827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00714 |
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