Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

APPL1 is an effector of the small GTPase Rab5. Together, they mediate a signal transduction pathway initiated by ligand binding to cell surface receptors. Interaction with Rab5 is confined to the amino (N)-terminal region of APPL1. We report the crystal structures of human APPL1 N-terminal BAR-PH do...

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Main Authors: Zhu, Guangyu, Chen, Jia, Liu, Jay, Brunzelle, Joseph S, Huang, Bo, Wakeham, Nancy, Terzyan, Simon, Li, Xuemei, Rao, Zihe, Li, Guangpu, Zhang, Xuejun C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933402/
https://ncbi.nlm.nih.gov/pubmed/17581628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601771
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