On Scaffold Hopping: Challenges in the Discovery of Sulfated Small Molecules as Mimetics of Glycosaminoglycans

Por Sidhu, Preetpal S., Mosier, Philip D., Zhou, Qibing, Desai, Umesh R.
Publicado em 2012

6-Hydroxyflavone and Derivatives Exhibit Potent Anti-Inflammatory Activity among Mono-, Di- and Polyhydroxylated Flavones in Kidney Mesangial Cells

Por Wang, Xing, Wang, Zhiwei, Sidhu, Preetpal Singh, Desai, Umesh R., Zhou, Qibing
Publicado no PLoS One (2015)

Genetic and pharmacological manipulation of Glyoxalase 1 regulates voluntary ethanol consumption in mice

Por McMurray, Katherine M. J., Sidhu, Preetpal S., Cook, James M., Arnold, Leggy A., Palmer, Abraham A.
Publicado no Addict Biol (2015)

Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin

Por Sidhu, Preetpal Singh, Liang, Aiye, Mehta, Akul Y., Abdel Aziz, May H., Zhou, Qibing, Desai, Umesh R.
Publicado em 2011

Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Sub-Sites That Can Be Targeted By Sulfated Small Molecules for Inducing Inhibition

Por Sidhu, Preetpal Singh, Abdel Aziz, May H., Sarkar, Aurijit, Mehta, Akul Y., Zhou, Qibing, Desai, Umesh R.
Publicado em 2013

GLO1 inhibitors for neuropsychiatric and anti-epileptic drug development

Por McMurray, Katherine M. J., Distler, Margaret G., Sidhu, Preetpal S., Arnold, Leggy A., Palmer, Abraham A., Plant, Leigh D.
Publicado em 2014

Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs

Por Teske, Kelly, Nandhikonda, Premchendar, Bogart, Jonathan W., Feleke, Belaynesh, Sidhu, Preetpal, Yuan, Nina, Preston, Joshua, Goy, Robin, Arnold, Leggy A.
Publicado no J Biomol Res Ther (2014)

Designing Allosteric Regulators of Thrombin. Monosulfated Benzofuran Dimers Selectively Interact With Arg173 of Exosite II to Induce Inhibition

Por Abdel Aziz, May H., Sidhu, Preetpal Singh, Liang, Aiye, Kim, Ji Yeong, Mosier, Philip D., Zhou, Qibing, Farrell, David H., Desai, Umesh R.
Publicado em 2012

A parallel chemistry approach to identify novel nuclear receptor ligands based on the GW0742 scaffold

Por Teske, Kelly A., Rai, Ganesha, Nandhikonda, Premchendar, Sidhu, Preetpal S., Feleke, Belaynesh, Simeonov, Anton, Yasgar, Adam, Jadhav, Ajit, Maloney, David J., Arnold, Leggy A.
Publicado no ACS Comb Sci (2017)

Development of Novel Vitamin D Receptor–Coactivator Inhibitors

Por Sidhu, Preetpal S., Nassif, Nicholas, McCallum, Megan M., Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y., Nandhikonda, Premchendar, Cook, James M., Singh, Rakesh K., Bikle, Daniel D., Arnold, Leggy A.
Publicado em 2014

IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING

Por Teske, Kelly, Nandhikonda, Premchendar, Bogart, Jonathan W., Feleke, Belaynesh, Sidhu, Preetpal, Yuan, Nina, Preston, Joshua, Goy, Robin, Han, Lanlan, Silvaggi, Nicholas R, Singh, Rakesh K., Bikle, Daniel D., Cook, James M., Arnold, Leggy A.
Publicado no Nucl Receptor Res (2014)

Identification of a novel, fast acting GABAergic anti-depressant

Por McMurray, Katherine M. J., Ramaker, Marcia J., Barkley-Levenson, Amanda M., Sidhu, Preetpal S., Elkin, Pavel, Reddy, M. Kashi, Guthrie, Margaret L., Cook, James M., Rawal, Viresh H., Arnold, Leggy A., Dulawa, Stephanie C., Palmer, Abraham A.
Publicado no Mol Psychiatry (2017)

Anticancer Activity of VDR-Coregulator Inhibitor PS121912

Por Sidhu, Preetpal S., Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y., Guthrie, Margaret L., Fernstrum, Grant B., Vyas, Nishita D., Han, Lanlan, Preston, Joshua, Bogart, Jonathan W., Silvaggi, Nicholas R., Cook, James M., Singh, Rakesh K., Bikle, Daniel D., Arnold, Leggy A.
Publicado em 2014

PT19c, Another Nonhypercalcemic Vitamin D(2) Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models

Por Kawar, Nada, Maclaughlan, Shannon, Horan, Timothy C., Uzun, Alper, Lange, Thilo S., Kim, Kyu K., Hopson, Russell, Singh, Ajay P., Sidhu, Preetpal S., Glass, Kyle A., Shaw, Sunil, Padbury, James F., Vorsa, Nicholi, Arnold, Leggy A., Moore, Richard G., Brard, Laurent, Singh, Rakesh K.
Publicado em 2013

Antitumor Activity of 3-Indolylmethanamines 31B and PS121912

Por Guthrie, Margaret L, Sidhu, Preetpal S., Hill, Emily K., Horan, Timothy C., Nandhikonda, Premchendar, Teske, Kelly A., Yuan, Nina Y., Sidorko, Marina, Kodali, Revathi, Cook, James M., Han, Lanlan, Silvaggi, Nicholas R., Bikle, Daniel D., Moore, Richard G., Singh, Rakesh K., Arnold, Leggy A.
Publicado no Anticancer Res (2015)

PPAR δ agonist GW0742 interacts weakly with multiple nuclear receptors including the vitamin D receptor

Por Nandhikonda, Premchendar, Yasgar, Adam, Baranowski, Athena M., Sidhu, Preetpal S., McCallum, Megan M., Pawlak, Alan J., Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y., Kevin, Chinedum, Bikle, Daniel D., Ayers, Steven D., Webb, Paul, Rai, Ganesha, Simeonov, Anton, Jadhav, Ajit, Maloney, David, Arnold, Leggy A.
Publicado em 2013