You are lost without a map: Navigating the sea of protein structures

Por Lamb, Audrey L., Kappock, T. Joseph, Silvaggi, Nicholas R.
Publicado no Biochim Biophys Acta (2014)

Binding Energy and Catalysis by D-Xylose Isomerase: Kinetic, Product and X-Ray Crystallographic Analysis of Enzyme-Catalyzed Isomerization of (R)-Glyceraldehyde(, )

Por Toteva, Maria M., Silvaggi, Nicholas R., Allen, Karen N., Richard, John P.
Publicado em 2011

Molecular Basis for ADP-ribose Binding to the Mac1 Domain of SARS-CoV-2 Nsp3

Por Frick, David N., Virdi, Rajdeep S., Vuksanovic, Nemanja, Dahal, Narayan, Silvaggi, Nicholas R.
Publicado no Biochemistry (2020)

Periplasmic Cytophaga hutchinsonii Endoglucanases Are Required for Use of Crystalline Cellulose as the Sole Source of Carbon and Energy

Por Zhu, Yongtao, Han, Lanlan, Hefferon, Kathleen L., Silvaggi, Nicholas R., Wilson, David B., McBride, Mark J.
Publicado no Appl Environ Microbiol (2016)

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies

Por Šilhár, Peter, Silvaggi, Nicholas R., Pellett, Sabine, Čapková, Kateřina, Johnson, Eric A., Allen, Karen N., Janda, Kim D.
Publicado em 2012

Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis

Por Vuksanovic, Nemanja, Zhu, Xuechen, Serrano, Dante A., Siitonen, Vilja, Metsä-Ketelä, Mikko, Melançon, Charles E., Silvaggi, Nicholas R.
Publicado no Acta Crystallogr F Struct Biol Commun (2020)

Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3

Por Virdi, Rajdeep S., Bavisotto, Robert V., Hopper, Nicholas C., Vuksanovic, Nemanja, Melkonian, Trevor R., Silvaggi, Nicholas R., Frick, David N.
Publicado no bioRxiv (2020)

Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3

Por Virdi, Rajdeep S., Bavisotto, Robert V., Hopper, Nicholas C., Vuksanovic, Nemanja, Melkonian, Trevor R., Silvaggi, Nicholas R., Frick, David N.
Publicado no SLAS Discov (2020)

Ligand Binding Phenomena that Pertain to the Metabolic Function of Renalase

Por Beaupre, Brett A., Roman, Joseph V., Hoag, Matthew R., Meneely, Kathleen M., Silvaggi, Nicholas R., Lamb, Audrey L., Moran, Graham R.
Publicado no Arch Biochem Biophys (2016)

A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis

Por Lee, Wenlin, McDonough, Michael A., Kotra, Lakshmi P., Li, Zhi-Hong, Silvaggi, Nicholas R., Takeda, Yoshifumi, Kelly, Judith A., Mobashery, Shahriar
Publicado em 2001

The Aspartate-Less Receiver (ALR) Domains: Distribution, Structure and Function

Por Maule, Andrew F., Wright, David P., Weiner, Joshua J., Han, Lanlan, Peterson, Francis C., Volkman, Brian F., Silvaggi, Nicholas R., Ulijasz, Andrew T.
Publicado no PLoS Pathog (2015)

Chirality Holds the Key for Potent Inhibition of the Botulinum Neurotoxin Serotype A Protease

Por Stowe, G. Neil, Šilhár, Peter, Hixon, Mark S., Silvaggi, Nicholas R., Allen, Karen N., Moe, Scott T., Jacobson, Alan R., Barbieri, Joseph T., Janda, Kim D.
Publicado em 2010

Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus: Functional Diversity in the Acetoacetate Decarboxylase-Li...

Por Burroughs, A. Maxwell, Hoppe, Robert W., Goebel, Neal C., Sayyed, Bilal H., Voegtline, Tyler J., Schwabacher, Alan W., Zabriskie, T. Mark, Silvaggi, Nicholas R.
Publicado em 2013

Swit_4259, an acetoacetate decarboxylase-like enzyme from Sphingomonas wittichii RW1

Por Mydy, Lisa S., Mashhadi, Zahra, Knight, T. William, Fenske, Tyler, Hagemann, Trevor, Hoppe, Robert W., Han, Lanlan, Miller, Todd R., Schwabacher, Alan W., Silvaggi, Nicholas R.
Publicado no Acta Crystallogr F Struct Biol Commun (2017)

Synthesis and Evaluation of Vitamin D Receptor-Mediated Activities of Cholesterol and Vitamin D Metabolites

Por Teske, Kelly A., Bogart, Jonathan W., Sanchez, Luis M., Yu, Olivia B., Preston, Joshua V., Cook, James M., Silvaggi, Nicholas R., Bikle, Daniel D., Arnold, Leggy A.
Publicado no Eur J Med Chem (2016)

RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization

Por Glanville, David G., Han, Lanlan, Maule, Andrew F., Woodacre, Alexandra, Thanki, Devsaagar, Abdullah, Iman Tajer, Morrissey, Julie A., Clarke, Thomas B., Yesilkaya, Hasan, Silvaggi, Nicholas R., Ulijasz, Andrew T.
Publicado no PLoS Pathog (2018)

IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING

Por Teske, Kelly, Nandhikonda, Premchendar, Bogart, Jonathan W., Feleke, Belaynesh, Sidhu, Preetpal, Yuan, Nina, Preston, Joshua, Goy, Robin, Han, Lanlan, Silvaggi, Nicholas R, Singh, Rakesh K., Bikle, Daniel D., Cook, James M., Arnold, Leggy A.
Publicado no Nucl Receptor Res (2014)

Anticancer Activity of VDR-Coregulator Inhibitor PS121912

Por Sidhu, Preetpal S., Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y., Guthrie, Margaret L., Fernstrum, Grant B., Vyas, Nishita D., Han, Lanlan, Preston, Joshua, Bogart, Jonathan W., Silvaggi, Nicholas R., Cook, James M., Singh, Rakesh K., Bikle, Daniel D., Arnold, Leggy A.
Publicado em 2014

Antitumor Activity of 3-Indolylmethanamines 31B and PS121912

Por Guthrie, Margaret L, Sidhu, Preetpal S., Hill, Emily K., Horan, Timothy C., Nandhikonda, Premchendar, Teske, Kelly A., Yuan, Nina Y., Sidorko, Marina, Kodali, Revathi, Cook, James M., Han, Lanlan, Silvaggi, Nicholas R., Bikle, Daniel D., Moore, Richard G., Singh, Rakesh K., Arnold, Leggy A.
Publicado no Anticancer Res (2015)

Small Molecule Metalloprotease Inhibitor with in Vitro, Ex Vivo and In Vivo Efficacy Against Botulinum Neurotoxin Serotype A

Por Jacobson, Alan R., Adler, Michael, Silvaggi, Nicholas R., Allen, Karen N., Smith, Genessa M., Fredenburg, Ross A., Stein, Ross L., Park, Jong-Beak, Mukherjee, Jean, Feng, Xiaochuan, Shoemaker, Charles B., Deshpande, Sharad S., Goodnough, Michael C., Malizio, Carl J., Johnson, Eric A., Pellett, Sabine, Tepp, William H., Tzipori, Saul
Publicado no Toxicon (2017)