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Small Molecule Metalloprotease Inhibitor with in Vitro, Ex Vivo and In Vivo Efficacy Against Botulinum Neurotoxin Serotype A

Botulinum neurotoxins (BoNTs) are the most toxic substances known to mankind and are the causative agents of the neuroparalytic disease botulism. Their ease of production and extreme toxicity have caused these neurotoxins to be classified as Tier 1 bioterrorist threat agents and have led to a sustai...

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Detalhes bibliográficos
Publicado no:Toxicon
Main Authors: Jacobson, Alan R., Adler, Michael, Silvaggi, Nicholas R., Allen, Karen N., Smith, Genessa M., Fredenburg, Ross A., Stein, Ross L., Park, Jong-Beak, Mukherjee, Jean, Feng, Xiaochuan, Shoemaker, Charles B., Deshpande, Sharad S., Goodnough, Michael C., Malizio, Carl J., Johnson, Eric A., Pellett, Sabine, Tepp, William H., Tzipori, Saul
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694348/
https://ncbi.nlm.nih.gov/pubmed/28698055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2017.06.016
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