An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists

Among the agents classified as “Category A” by the U.S. Centers for Disease Control and Prevention, botulinum neurotoxin (BoNT) is the most toxic protein known, with microgram quantities of the protein causing severe morbidity and mortality by oral or i.v. routes. Given that this toxin easily could...

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Detalhes bibliográficos
Main Authors: Eubanks, Lisa M., Hixon, Mark S., Jin, Wei, Hong, Sukwon, Clancy, Colin M., Tepp, William H., Baldwin, Michael R., Malizio, Carl J., Goodnough, Michael C., Barbieri, Joseph T., Johnson, Eric A., Boger, Dale L., Dickerson, Tobin J., Janda, Kim D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815229/
https://ncbi.nlm.nih.gov/pubmed/17293454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611213104
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