An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists

Among the agents classified as “Category A” by the U.S. Centers for Disease Control and Prevention, botulinum neurotoxin (BoNT) is the most toxic protein known, with microgram quantities of the protein causing severe morbidity and mortality by oral or i.v. routes. Given that this toxin easily could...

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Hlavní autoři: Eubanks, Lisa M., Hixon, Mark S., Jin, Wei, Hong, Sukwon, Clancy, Colin M., Tepp, William H., Baldwin, Michael R., Malizio, Carl J., Goodnough, Michael C., Barbieri, Joseph T., Johnson, Eric A., Boger, Dale L., Dickerson, Tobin J., Janda, Kim D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815229/
https://ncbi.nlm.nih.gov/pubmed/17293454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611213104
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