An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists

Among the agents classified as “Category A” by the U.S. Centers for Disease Control and Prevention, botulinum neurotoxin (BoNT) is the most toxic protein known, with microgram quantities of the protein causing severe morbidity and mortality by oral or i.v. routes. Given that this toxin easily could...

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Bibliografiske detaljer
Main Authors: Eubanks, Lisa M., Hixon, Mark S., Jin, Wei, Hong, Sukwon, Clancy, Colin M., Tepp, William H., Baldwin, Michael R., Malizio, Carl J., Goodnough, Michael C., Barbieri, Joseph T., Johnson, Eric A., Boger, Dale L., Dickerson, Tobin J., Janda, Kim D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815229/
https://ncbi.nlm.nih.gov/pubmed/17293454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611213104
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